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Hyperhydrophilic fluorine-19 magnetic resonance imaging contrast agent is a probe that uses a fluorine-containing ionic liquid or a zwitterionic polymer as a fluorine source to wrap or modify it with nanomaterials or biomolecules. Superhydrophilic fluorine-19 MR imaging contrast agents have high water solubility, high fluorine content, high SNR, low toxicity and high stability, which can overcome the defects of traditional fluorine-19 MR imaging contrast agents, such as hydrophobicity, signal attenuation, and background interference. A hyper-hydrophilic fluorine-19 magnetic resonance imaging contrast agent based on liquid-solid phase transition was prepared by loading and encapping hollow mesoporous silica nanoparticles using a fluorine-containing liquid as a fluorine source. The contrast agent can realize the responsive imaging of various biometric targets (such as metalloproteinase, acidic environment, etc.) through the "off-on" mechanism, and realize the accurate positioning and quantitative calculation of the tumor at the living body level.

Reference Documentation:

[1]Zhu X, Chen Y, Zhang C, et al. A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Detects Biological Targets[J]. Chem, 2020, 6(3): 713-728. https://www.cell.com/chem/fulltext/S2451-9294(20)30047-4

[2]Feng Z, Li Q, Wang W, et al. Superhydrophilic fluorinated polymer and nanogel for high-performance 19F magnetic resonance imaging[J]. Biomaterials, 2020, 255: 120184. https://www.sciencedirect.com/science/article/pii/S0142961220304184