Multi-barrier programmed nanodelivery strategies and real-time detection devices
跨多屏障程序化納米遞送策略是一種利用納米材料和外部刺激來實現藥物或基因在體內的精準、可控和高效的遞送的技術，它可以克服生理屏障、細胞屏障和核屏障等多種阻礙，從而提高藥物的生物利用度和治療效果。程序化納米遞送策略可以根據藥物的性質、目標組織的特征、病理狀態的變化等因素，設計不同的響應機制和釋放模式，以實現藥物的定時、定量、定向和定位的遞送。
實時檢測器件是一種利用光學、電化學、生物傳感等手段來監測納米遞送系統在體內的分布、運輸、釋放和作用的技術，它可以提供對納米遞送系統的實時反饋和調控，從而優化藥物的療效和安全性。實時檢測器件可以與納米遞送系統結合，形成一體化的智能平臺，或者單獨使用，作為輔助工具來評估納米遞送系統的性能。
Multi-barrier programmed nanodelivery strategy is a technique that enables precise, controlled, and efficient delivery using nanomaterials and external stimuli, which can overcome multiple obstacles such as physiological, cellular, and nuclear barriers, thus improving drug bioavailability and therapeutic efficacy. Programmed nanodelivery strategies can design different response mechanisms and release patterns based on the nature of the drug, characteristics of the target tissue, and changes in pathological state, to achieve timing, quantitative, directed, and localized delivery of drugs.
Real-time detection device is a technology that monitors the distribution, transportation, release and action of the nanodelivery system by using optics, electrochemical and biosensing means in the body. It can provide real-time feedback and regulation of the nanodelivery system, so as to optimize the efficacy and safety of drugs. Real-time detection devices can be combined with nanodelivery systems to form an integrated intelligent platform or, used alone, as an auxiliary tool to evaluate the performance of the nanodelivery system.
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