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Antitumor study of nanomaterials for targeted degradation of mutant p53 is a novel strategy that uses nanomaterials as carriers to couple molecules or enzymes capable of identifying and degrade mutant p53 with them, so as to realize accurate diagnosis and treatment of tumor cells. The p53 is an important tumor suppressor gene that can regulate various anti-tumor processes such as cell cycle, apoptosis, and autophagy. However, p53 is mutated in a variety of human cancers, leading in its loss of normal function and even gain of cancer-promoting function. Therefore, targeted degradation of mutant p53 is an effective antitumor approach.

A coupling based on pyrrole-imidazole polyamide (PIP) and proteasome inhibitor (PI) that specifically recognizes and degrade mutant p53. This coupling can bind to the gene with mutant p53, block its transcription and promote its degradation through the proteasome pathway, thereby inhibiting tumor cell proliferation and migration.