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Coordination polymer drug delivery system is a kind of degradable polymer composed of metal ions and organic ligands through coordination bonds, which can be used as a carrier of immunotherapeutic drugs to achieve accurate diagnosis and treatment of tumors. Coordination polymer drug delivery system have been widely used in tumor immunotherapy with adjustable structure, functional design, high biocompatibility and good biodegradability. In tumor immunotherapy, coordinate polymer drug delivery system can be through different design, improve its targeting in the tumor site, stability and controlled release, at the same time also can through different functions, achieve multimodal diagnosis and treatment of tumor, such as photodynamic therapy, photothermal therapy, chemotherapy and immunotherapy, etc.