国产人妖在线视频I午夜av一区二区三区I国产色一区二区I一级片视频在线观看I一级毛片儿I亚色图I丁香花一区二区I超碰97在线免费I久久精品中文字幕I日韩在线视频观看免费I无码中文字幕色专区I欧美专区亚洲专区I国产tv在线观看I2024最新黄色网址I日本老妇高潮乱hdI成人免费入口I日韩精品视频在线看I国产传媒在线播放I一本岛视频在线观看I自拍日韩亚洲一区在线I国产成人亚洲综合a∨婷婷I国产精品2019I色亚洲天堂Iav黄色免费I欧美大尺度视频

Immunotherapy based on natural killer (NK) cells is considered to be an important cell-based cancer treatment strategy. It has a good therapeutic effect on early tumor and tumor metastasis, but its therapeutic effect on solid tumor is not ideal. In vitro activation of NK cells with exogenous cytokines is one of the necessary steps in treatment, but it is difficult to produce high dose of functional NK cells for cancer treatment. Imaging guided local NK cell delivery can also be used for treatment, but there is still a lack of non-invasive imaging tools to monitor NK cells.

In this study, Dong Hyun Kim of Northwestern University used clinically available materials (hyaluronic acid, protamine and nano iron oxide; HAPF) developed a magnetic nanocomposite and used it to label NK cells.

The main points of this paper are as follows:

 (1) the prepared HAPF nanocomposites can effectively adhere to NK cells (hapf-nk). Under the effect of exogenous magnetic field, NK cells can be activated, and then promote the production and secretion of lysates. At the same time, magnetic activated hapf-nk cells can also achieve MRI guided NK cell therapy and transcatheter arterial infusion (IA) to treat hepatocellular carcinoma (HCC) solid tumors.

(2) Studies have shown that ia injection of magnetically activated NK cells can inhibit tumor growth, which proves that imaging guided local delivery of magnetically activated hapf-nk cells has a good therapeutic effect. In conclusion, this study shows that HAPF labeled NK cells can significantly improve the therapeutic effect of NK cells through magnetic activation and MRI.

This information is from the Internet for academic exchange only. If there is any infringement, please contact us to delete it immediately