Nanozyme：Au/Cu-TCPP(Fe)@RSL3-PEG-iRGD
| 【Numbering】BKMA104019 | 【CAS】CAS | ||
| 【Item No.】BKMA104019-2 | 【specification】 | ||
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Name: Au / Cu-TCPP (Fe) @ RSL 3-PEG-iRGD
Composition: Au, Cu-TCPP (Fe), RSL 3, PEG, and iRGD
Particle size: 100 nm
Application: triple-negative breast cancer treatment
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] 1. After TNBC cells have targeted uptake of composite nanosheets by iRGD, Gold nanoparticles on nanosheets can deplete intracellular glucose through their GOx-like catalytic activity, Disairs the pentose phosphate pathway (PPP) in TNBC cells, And increase the NADP + / NADPH ratio, Thus hindering the circulation of coenzyme Q10 to coenzyme Q10H2; 2. Coenzyme Q10H2 is a key antioxidant used to capture lipid peroxy radicals in the FSP 1-mediated antiiron death pathway; 3, the increase of the NADP + / NADPH ratio also further inhibited the conversion of cystine to cysteine, And inhibit GSH and GPX 4 synthesis; 4, in addition to the iron-death regulation of gold nanoparticles, Copper in the nanosheets can directly react with the GSH molecules, And oxidize it to a nonactivatable GSSG, Further inhibiting the detoxification capacity of the GPX 4-mediated lipid-peroxide reduction system.
Title:Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy
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Composition: Au, Cu-TCPP (Fe), RSL 3, PEG, and iRGD
Particle size: 100 nm
Application: triple-negative breast cancer treatment
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] 1. After TNBC cells have targeted uptake of composite nanosheets by iRGD, Gold nanoparticles on nanosheets can deplete intracellular glucose through their GOx-like catalytic activity, Disairs the pentose phosphate pathway (PPP) in TNBC cells, And increase the NADP + / NADPH ratio, Thus hindering the circulation of coenzyme Q10 to coenzyme Q10H2; 2. Coenzyme Q10H2 is a key antioxidant used to capture lipid peroxy radicals in the FSP 1-mediated antiiron death pathway; 3, the increase of the NADP + / NADPH ratio also further inhibited the conversion of cystine to cysteine, And inhibit GSH and GPX 4 synthesis; 4, in addition to the iron-death regulation of gold nanoparticles, Copper in the nanosheets can directly react with the GSH molecules, And oxidize it to a nonactivatable GSSG, Further inhibiting the detoxification capacity of the GPX 4-mediated lipid-peroxide reduction system.
Title:Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy
Article link:https://mp.weixin.qq.com/s?src=11×tamp=1688722160&ver=4636&signature=PFZ*ui5DhCoRpyBLkZpAdluuPBum8QM-MAxyfcGqH9bCuVQ-fucEp6rc-nfOhLSkCugJZLOoPDMWYX5S*2ZrSAEXLxR2hwmml8OWKewBSPXVjzlxnm69bH0VLGmVmMVF&new=1
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance.The website pictures are from the Internet. The pictures are for reference only. Please take the real object as the standard. In case of infringement, please contact us to delete them immediately. |
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