Hydrogels：酶觸發(fā)的L-α/D-多肽水凝膠
| 【Numbering】BKMB100012 | 【CAS】CAS | ||
| 【Item No.】BKMB100012-2 | 【specification】 | ||
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Name: Enzyme-triggered L- α / D-polypeptide hydrogel
Composition: NapFFKY (p) G-OH, antiretroviral drugs
Particle size: network structure, hole: 200-500nm
Application: Long-term treatment of AIDS
Storage conditions: -4℃
Other instructions: Half shelf life in sealed state [Main Advantages] The implant consists of self-assembly of ultra-short peptide aqueous gel factors and is covalently coupled with zidovudine through an ester bond. Under physiological conditions (37 C, pH=7.4, H2O), ester bond hydrolysis, release of the drug into the surrounding medium, the unchemically modified drug helps to maintain the therapeutic effect and reduce the metabolic toxicity after release.
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Composition: NapFFKY (p) G-OH, antiretroviral drugs
Particle size: network structure, hole: 200-500nm
Application: Long-term treatment of AIDS
Storage conditions: -4℃
Other instructions: Half shelf life in sealed state [Main Advantages] The implant consists of self-assembly of ultra-short peptide aqueous gel factors and is covalently coupled with zidovudine through an ester bond. Under physiological conditions (37 C, pH=7.4, H2O), ester bond hydrolysis, release of the drug into the surrounding medium, the unchemically modified drug helps to maintain the therapeutic effect and reduce the metabolic toxicity after release.
Title:Enzyme-Triggered l-α/d-Peptide Hydrogels as a Long-Acting Injectable Platform for Systemic Delivery of HIV/AIDS Drugs
Article link:https://doi.org/10.1002/adhm.202203198
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